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Related Concept Videos

Glial Cells01:04

Glial Cells

Overview
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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Related Experiment Video

Updated: Jun 18, 2026

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
07:54

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Microglia and central nervous system immunity.

Gurvinder Kaur1, Seunggu J Han, Isaac Yang

  • 1Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Avenue, One Shrader Street, Suite 650, San Francisco, CA 94117, USA.

Neurosurgery Clinics of North America
|December 1, 2009
PubMed
Summary
This summary is machine-generated.

Microglia, the brain's immune cells, play a key role in central nervous system (CNS) immunity and glioma development. Understanding their function is crucial for advancing CNS disease and tumor immunology research.

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Last Updated: Jun 18, 2026

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07:54

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09:12

Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

Published on: January 30, 2014

Area of Science:

  • Neuroimmunology
  • Oncology
  • Central Nervous System (CNS) Research

Background:

  • The CNS is immune-privileged, requiring specialized surveillance systems.
  • Microglia, resident macrophages in the CNS, are central to this surveillance.
  • Microglia accumulation is observed in various CNS diseases, including tumors.

Purpose of the Study:

  • To discuss the role of microglia in CNS immunity.
  • To highlight advances in understanding microglia's involvement in glioma immunology.
  • To explore microglia's contribution to the immunosuppressive tumor microenvironment.

Main Methods:

  • Review of recent advances in CNS disease processes.
  • Analysis of the role of microglia in glioma immunology.
  • Discussion of microglia accumulation in CNS diseases.

Main Results:

  • Microglia contribute to the immunosuppressive environment in gliomas.
  • Microglia promote glioma tumor growth.
  • Microglia are implicated in nearly all CNS disease processes.

Conclusions:

  • Microglia are critical players in CNS immunity and surveillance.
  • Targeting microglia may offer new therapeutic strategies for gliomas.
  • Further research into microglia function is essential for CNS disease and cancer immunology.