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[Preventive effects of pueraria on presbycusis in rats]
Wangyan Chen1, Qi Yao, Weihong Liu
1Department of Otorhinolaryngology, Chinese and Western Medicine Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China. meniere@163.com
Objective:
To investigate the preventive effects of Pueraria on presbycusis in rats.
Method:
Thirty-two 24-26 month old Wistar rats were randomly divided into four groups, and were treated with different dosages of Pueraria (1, 2, 4, 0 g x kg(-1) x d(-1)) separately for 4 weeks. Auditory brainstem response (ABR) was used to detect the change of hearing threshold of rats. Hemorheological items of rats were checked in each group.
Result:
Compared with control group, the hearing threshold and hemorheological items of rats was significantly improved after treated with Pueraria (P<0.05). In addition, 2 g/(kg x d) was found to be the best dosage of Pueraria for rats, which can achieve ideal effect with minimum side effect.
Conclusion:
Pueraria could improve tiny circulation, has good preventive effect on presbycusis of rats.
