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Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...

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Updated: Jun 17, 2026

Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

Published on: January 20, 2018

Dynamic control over cell adhesive properties using molecular-based surface engineering strategies.

Jort Robertus¹, Wesley R Browne, Ben L Feringa

¹Stratingh Institute of Chemistry and Centre for Systems Chemistry, Faculty of Mathematics and Natural Sciences, University of Groningen, Groningen, Nijenborgh 4, 9747AG Groningen, The Netherlands.

Chemical Society Reviews

|December 22, 2009

Summary

This summary is machine-generated.

Researchers are exploring dynamic control over cell adhesion to artificial surfaces using external stimuli. This review covers recent advances in self-assembled monolayers (SAMs) for controlled cell attachment, crucial for tissue engineering and drug screening.

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Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation

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Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Published on: March 8, 2017

Area of Science:

Biomaterials Science
Cell Biology
Surface Chemistry

Background:

Cells rely on the extracellular matrix (ECM) for structural integrity and regulated cellular processes.
Controlling cell-surface interactions dynamically offers significant potential in tissue engineering, medicine, and immunology.
Spatial control over cell adhesion is valuable for developing cell-based screening devices and studying cellular behaviors.

Purpose of the Study:

To critically review recent developments in controlling mammalian cell adhesion to stimulus-responsive surfaces.
To highlight the potential of dynamic control over cell-surface interactions for various applications.
To identify current limitations and future directions in reversible cell adhesion control.

Main Methods:

Review of recent literature on self-assembled monolayers (SAMs) modified for external stimulus response (e.g., light, electrochemistry).
Analysis of studies demonstrating controlled cell adhesion and spreading on these dynamic surfaces.
Discussion of physical properties of SAMs that enable stimulus-induced changes in cell interaction.

Main Results:

Significant progress has been made in developing surfaces where cell adhesion can be modulated by external stimuli.
Self-assembled monolayers (SAMs) offer a versatile platform for achieving dynamic control over cell attachment.
Stimulus-responsive SAMs enable patterned cell spreading and controlled cell behavior for research and applications.

Conclusions:

Dynamic control over cell adhesion to artificial surfaces is an emerging field with substantial promise.
Further research is needed to achieve robust and reversible control of cell adhesion for widespread application.
Stimulus-responsive SAMs are key to advancing tissue engineering, drug discovery, and cell-based technologies.