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Updated: Jun 17, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis
Huihua Sun1, Rong Kong, Di Zhu
1School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551.
Abstract:
The iterative polyketide synthases from the biosynthetic pathways of three enediyne natural products were examined. The results established the all-trans conjugated pentadecaheptanene as the only major product shared by the PKSs. The experiments further revealed some intrinsic differences among the PKSs by demonstrating the formation of different by-products.
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