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Hyperfractionated irradiation for adults with brainstem gliomas.
D E Linstadt1, M S Edwards, M Prados
1Department of Radiation Oncology, UCSF 94143.
Summary
Hyperfractionated radiotherapy shows promise for adult brainstem gliomas, improving survival and local control with good tolerance. This technique warrants further investigation for brain tumor treatment.
Area of Science:
- Radiation Oncology
- Neuro-oncology
- Medical Physics
Background:
- Hyperfractionated irradiation has shown improved survival in pediatric brainstem gliomas.
- Efficacy and safety data for this technique in adult brainstem tumors are limited.
Purpose of the Study:
- To evaluate the efficacy and safety of hyperfractionated irradiation for adult brainstem gliomas.
Main Methods:
- 14 adult patients with brainstem gliomas received 100 cGy fractions twice daily to a median dose of 7200 cGy.
- Follow-up ranged from 4-69 months, with analysis of survival, local control, and toxicity.
Main Results:
- 3-year actuarial survival was 59%, with a 48% local control rate.
- Median survival exceeded 5 years; median time to progression was 31 months.
- Treatment was well-tolerated, with most patients maintaining or improving Karnofsky Performance Status and no severe long-term complications.
Conclusions:
- Hyperfractionated irradiation appears to offer improved outcomes for adult brainstem gliomas compared to conventional radiotherapy.
- The technique is well-tolerated and warrants further investigation for this patient population.