Maximizing safe design of engineered nanomaterials: the NIH and NIEHS research perspective

Estimating potential risk of an emerging technology as its products are being developed offers the greatest potential for success of the technology. The National Nanotechnology Initiative was launched in 2000 to provide a federal framework to support safe and responsible development of nanotechnology.Within this framework, the National Institutes of Health (NIH) focuses resources and expertise on both the biomedical applications of nanotechnology and the possibility of adverse health effects, or implications research. NIH developed the NanoHealth and Safety Enterprise Initiative by identifying shared research needs across the nanotechnology applications and implications research communities to create an integrated research strategy to maximize resources and expedite the development of engineered nanomaterials (ENM) that are safe by design. The central goal of this program is to decipher the fundamental principles of ENM interactions with biological systems that are relevant to human exposure and physiological response. Program components include materials science, basic biology, pathobiology, and informatics, as well as a cross-disciplinary training program for new nanotechnology scientists. The magnitude of this program will be best supported by flexible, dynamic funding and research mechanisms including the formation of public-private partnerships that span the expertise and interests of government, industry, academia, public interest, and other stakeholders. It is through such innovative, integrated, and cross-disciplinary programs that the full promise of nanotechnology may be realized while ensuring that this emerging field does not succumb to hidden perils.