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Updated: Jun 17, 2026
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Interlead distance and left ventricular lead electrical delay predict reverse remodeling during cardiac
Faisal M Merchant1, E Kevin Heist, K Veena Nandigam
1Cardiology Division, Massachusetts General Hospital Heart Center, Harvard Medical School, Boston, Massachusetts 02114, USA.
Pacing and Clinical Electrophysiology : PACE
|January 15, 2010
Summary
Optimizing both left ventricular lead electrical delay and interlead distance improves cardiac resynchronization therapy outcomes. Combining these measurements offers better prediction of reverse left ventricular remodeling.
Area of Science:
- Cardiology
- Medical Imaging
- Biomedical Engineering
Background:
- Cardiac resynchronization therapy (CRT) outcomes are influenced by interlead separation and left ventricle lead electrical delay (LVLED).
- The combined predictive value of interlead distance and LVLED for CRT success was previously undefined.
Purpose of the Study:
- To investigate the relationship between interlead distance and LVLED.
- To determine if these parameters synergistically predict reverse left ventricular remodeling after CRT.
Main Methods:
- Sixty-one patients undergoing CRT had LVLED measured intraprocedurally.
- Interlead distances (horizontal, vertical, direct) were measured from chest radiographs.
- Left ventricular remodeling was assessed via echocardiography.
Main Results:
- LVLED correlated positively with horizontal distance and negatively with vertical distance.
- A composite anatomic distance metric showed the strongest correlation with LVLED (r = 0.404, P = 0.001).
- Optimal LVLED and composite distance predicted superior reverse left ventricular remodeling.
Conclusions:
- A significant correlation exists between LV-right ventricular interlead distance and LVLED.
- Both interlead distance and LVLED synergistically predict reverse left ventricular remodeling.
- Optimizing both parameters may enhance CRT outcomes.
