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Updated: Jun 17, 2026

Germ Cell Transplantation and Testis Tissue Xenografting in Mice
Published on: February 6, 2012
Testicular germline stem cells
Kehkooi Kee1, Renee A Reijo Pera, Paul J Turek
1Center for Human Embryonic Stem Cell Research and Education, Institute for Stem Cell Biology & Regenerative Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford University, Palo Alto, CA 94305, USA.
Abstract:
Stem cells have the ability to both differentiate into other mature cell types and maintain an undifferentiated state by self-renewal. These unique properties form the basis for stem cell use in organ replacement and tissue regeneration in clinical medicine. Currently, embryonic stem cells are the best-studied stem cell type. However alternative stem cells such as induced pluripotent stem cells and other adult stem cells are also being actively investigated for their potential for cell-based therapy. Among adult stem cells, emerging research has focused on evaluating the pluripotency potential of testis stem cells. To date, stem cells with embryonic-like potential have been created from adult testis germ cells. These cells could provide patient-specific, non-embryo-derived stem cells for men in the future.
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