Related Experiment Videos
[What's new in internal medicine?].
1Service de Médecine Interne, Hôpital Foch, Suresnes, France. o.bletry@hopital-foch.org
Annales De Dermatologie Et De Venereologie
|January 30, 2010
Summary
Recent advancements in internal medicine include improved diagnosis of Antisynthetase Syndrome and unexplained hyperferritinemia. New therapies target autoimmune and autoinflammatory diseases with biologics like interleukin inhibitors.
Area of Science:
- Internal Medicine
- Rheumatology
- Immunology
Context:
- Diagnostic progress in internal medicine over the last three years.
- Increased recognition of Antisynthetase Syndrome through antibody testing.
- Understanding of unexplained hyperferritinemia via genetic mutations.
Purpose:
- To review recent diagnostic and therapeutic advancements in internal medicine.
- To highlight key developments in autoimmune and autoinflammatory diseases.
- To emphasize the role of novel biological therapies.
Summary:
- Antisynthetase Syndrome is more easily diagnosed with tRNA synthetase antibody tests (Anti JO1, PL7, PL12), often positive without antinuclear antibodies.
- Asymptomatic L ferritin gene mutations aid understanding of unexplained hyperferritinemia.
- Autoimmune pancreatitis is linked to IgG4-related systemic disease.
- A new pediatric disease of interleukin-1 receptor antagonist deficiency clarifies autoinflammatory conditions.
- Biological therapies, including IL-1, IL-5, and IL-6 inhibitors, and anti-VEGF agents, offer new treatment options for various internal medicine conditions.
Impact:
- Improved diagnostic capabilities for complex syndromes.
- Enhanced understanding of the pathogenesis of autoimmune and autoinflammatory diseases.
- Expansion of therapeutic options with targeted biological agents.
Related Concept Videos
01:12Internal Anatomy of the Kidney
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
01:30Current Trends in Nursing II
Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
01:29Microorganisms in Medicine and Therapeutics
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
01:27Nursing Clinical Information System
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
01:14Myocarditis III: Medical Management
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...