Related Experiment Video
Updated: May 6, 2026
RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 12, 2014
[Expression of Survivin and Bcl-2 in sinonasal inverted papilloma]
Jinhui Liang1, Shan Gao, Jian Zhang
1Department of Otolaryngology, Central Hospital of Hanzhong, Hanzhong, 723000, China. jackydoctor@sohu.com
Objective:
To investigate the expression of Survivin and its relationship with the expression of Bcl-2 in sinonasal inverted papilloma (SNIP).
Method:
Immunohistochemical method was used to determine the expression of Survivin and Bcl-2 in 30 cases of SNIP, 10 cases of sinonasal squamous cell carcinoma (SCC) and 10 cases of normal inferior concha tissues.
Result:
Survivin was expressed in 22 of 30 (73.3%) cases of SNIP, 8 of 10 (80.0%) cases of SCC and not expressed in 10 (0%) cases of normal inferior concha tissues. Expression of Survivin was significantly higher in SNIP and SCC than in normal tissues. Bcl-2 was expressed in 9 of 10 (90.0%) cases of SCC and 2 of 10 (20.0%) cases of normal inferior concha tissues. Expression of Bcl-2 was significantly higher in SCC than in normal tissues. Bcl-2 was expressed in 14 of 30 (46.7%) cases of SNIP, higher than normal tissues. Expression of Bcl-2 was positively related to expression of Survivin.
Conclusion:
Survivin may play an important role in the pathway of progression of SNIP and SCC. It may be identified as a new therapeutic target. Bcl-2 may play a synergic role with Survivin in progression of SNIP.
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:31The Intrinsic Apoptotic Pathway