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A molecular mechanism for proton-dependent gating in KcsA

Luis G Cuello1, D Marien Cortes, Vishwanath Jogini

  • 1Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA.

FEBS Letters
|February 9, 2010
PubMed
Summary

Proton concentration changes activate KcsA channel gating. A key charge cluster, involving specific residues, stabilizes the closed state at neutral pH and drives opening at low pH via electrostatic repulsion.

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