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Related Concept Videos

Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...

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Related Experiment Video

Updated: Jun 16, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Gene-based vaccines: Recent developments.

Margaret A Liu1

  • 1ProTherImmune, Lafayette, CA 94549, USA. liu@protherimmune.com

Current Opinion in Molecular Therapeutics
|February 9, 2010
PubMed
Summary
This summary is machine-generated.

Gene-based vaccines show promise for treating infectious diseases, cancer, and autoimmune conditions in both humans and animals. Recent studies highlight advancements in potency and immune mechanisms for these innovative therapies.

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Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes
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Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

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Last Updated: Jun 16, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

Area of Science:

  • Biotechnology
  • Immunology
  • Veterinary Medicine

Background:

  • Gene-based vaccines are emerging as versatile tools for various medical applications.
  • Recent approvals in veterinary medicine demonstrate the efficacy of DNA vaccines and immunotherapies.
  • Growing research focuses on enhancing gene-based vaccine potency and understanding underlying immune responses.

Purpose of the Study:

  • To review recent advancements in gene-based vaccine technologies.
  • To survey diseases and approaches targeted by gene-based vaccines.
  • To discuss progress and observations in preclinical and clinical studies.

Main Methods:

  • Literature review of recent publications on gene-based vaccines.
  • Survey of diseases and therapeutic strategies.
  • Analysis of studies on vaccine potency and immune mechanisms.

Main Results:

  • Gene-based vaccines are being developed for infectious diseases, cancer, autoimmune diseases, and allergies.
  • Successful veterinary applications include fish, shrimp, cattle, and horses.
  • Research is actively improving vaccine potency and elucidating immune responses.

Conclusions:

  • Gene-based vaccines represent a rapidly advancing field with broad therapeutic potential.
  • Ongoing research continues to refine these technologies for human and animal health.
  • The review synthesizes current progress and future directions in gene-based vaccinology.