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09:16
Orthotopic Small Bowel Transplantation in Rats
Published on: November 6, 2012
Outcomes in children after intestinal transplant
Oliver B Lao1, Patrick J Healey, James D Perkins
1University of Washington, Department of Surgery, 1959 NE Pacific St, Box 356410, Seattle, WA 98195, USA. olao@uw.edu
Pediatrics
|February 10, 2010
Summary
Pediatric intestinal transplant survival varies by diagnosis. Children with volvulus showed better survival rates compared to those with gastroschisis, highlighting the impact of underlying disease on outcomes.
Area of Science:
- Pediatric surgery
- Transplantation immunology
- Gastroenterology
Background:
- Pediatric intestinal transplantation is a complex procedure for intestinal failure.
- Survival rates and influencing factors based on underlying disease are not well-established.
Purpose of the Study:
- To describe the characteristics of pediatric patients undergoing intestinal transplantation.
- To evaluate patient survival rates in relation to specific underlying diseases.
Main Methods:
- Retrospective analysis of the United Network for Organ Sharing (UNOS) intestinal transplant database (1991-2008).
- Inclusion of pediatric patients (<=21 years) with intestinal failure.
- Kaplan-Meier survival analysis and Cox regression to assess outcomes by diagnosis.
Main Results:
- 852 pediatric intestinal transplants were performed; 69% included a simultaneous liver transplant.
- Common diagnoses included gastroschisis (24%), necrotizing enterocolitis (15%), and volvulus (14%).
- Significant differences in survival were observed based on diagnosis (P < .001), with volvulus demonstrating a survival advantage over gastroschisis.
Conclusions:
- Underlying disease significantly impacts survival after pediatric intestinal transplantation.
- Further research is needed to understand the specific characteristics contributing to survival differences among pediatric intestinal failure populations.
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