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Insulin: Dosing Regimen and Adverse Effects

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Related Experiment Video

Updated: Jun 16, 2026

Improving IV Insulin Administration in a Community Hospital

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Clinical update on optimal prandial insulin dosing using a refined run-to-run control algorithm.

Howard Zisser¹, Cesar C Palerm, Wendy C Bevier

¹Sansum Diabetes Research Institute, Santa Barbara, California, USA.

Journal of Diabetes Science and Technology

|February 11, 2010

Summary

A novel algorithm improved prandial insulin dosing for type 1 diabetes (T1DM) management by optimizing insulin-to-carbohydrate ratios. This approach helps maintain better blood glucose control after meals.

Related Experiment Videos

Last Updated: Jun 16, 2026

Improving IV Insulin Administration in a Community Hospital

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Area of Science:

Endocrinology
Metabolic Diseases
Computational Biology

Background:

Type 1 diabetes (T1DM) management requires precise insulin dosing.
Optimizing prandial insulin-to-carbohydrate ratios (I:CHO) is crucial for postmeal glucose control.
Traditional methods may not adequately address variable meal carbohydrate content.

Purpose of the Study:

To evaluate a novel run-to-run algorithm for optimizing prandial insulin dosing in T1DM.
To calculate meal-specific insulin-to-carbohydrate ratios (I:CHO) using daily glucose data.
To assess the algorithm's effectiveness in managing postprandial hyperglycemia.

Main Methods:

An open-labeled, nonrandomized study involving nine T1DM subjects using continuous subcutaneous insulin infusion.
Basal insulin rates were optimized; subjects maintained premeal glucose between 70-130 mg/dl.
Daily glucose monitoring and algorithm-derived I:CHO ratios informed prandial insulin boluses over 6 weeks.

Main Results:

Mean 1-hour postprandial blood glucose was 104 +/- 19 mg/dl.
Mean 2-hour postprandial glucose levels (96.5 +/- 18 mg/dl) neared preprandial levels (90.1 +/- 13 mg/dl).
The algorithm demonstrated effective glucose level management after meals.

Conclusions:

Run-to-run algorithms can significantly improve postprandial blood glucose control in T1DM.
This computational approach offers a promising strategy for personalized diabetes management.
Refined algorithms enhance the ability to adjust insulin dosing for variable meal intakes.