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Related Experiment Video

Updated: Jun 16, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor
11:11

Construction and Characterization of a Novel Vocal Fold Bioreactor

Published on: August 1, 2014

Functional testing of a tissue-engineered vocal fold cover replacement.

Jennifer L Long1, Juergen Neubauer, Zhaoyan Zhang

  • 1Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. jlong@mednet.ucla.edu

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|February 23, 2010
PubMed
Summary

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Dynamic 3D MRI of vocal fold oscillations: In vivo assessment of vocal fold thickness, contact area, and glottal area waveform across phonation types in comparison with high-speed imaging.

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Tissue engineering successfully created vocal fold cover replacements. These bilayered constructs mimic human vocal fold mechanical properties and vibrate during phonation, offering a promising treatment for vocal fold scarring.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Otolaryngology

Background:

  • Severe vocal fold scars impair voice quality.
  • Current treatments for vocal fold scarring have limitations.
  • Tissue engineering offers a potential solution for vocal fold repair.

Purpose of the Study:

  • To quantify the mechanical properties of tissue-engineered vocal fold cover replacements.
  • To demonstrate the vibratory capacity of these engineered constructs.
  • To compare bilayered and homogeneous engineered vocal fold constructs.

Main Methods:

  • Tissue-engineered constructs were fabricated using fibrin and adipose-derived stem cells.
  • Optimized bilayered constructs featured stratified epithelial and mesenchymal cells.

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Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication
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Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication

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Manufacturing Process for Non-Adhesive Super-Soft Vocal Fold Models
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Manufacturing Process for Non-Adhesive Super-Soft Vocal Fold Models

Published on: January 5, 2024

Related Experiment Videos

Last Updated: Jun 16, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor
11:11

Construction and Characterization of a Novel Vocal Fold Bioreactor

Published on: August 1, 2014

Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication
10:16

Synthetic, Multi-Layer, Self-Oscillating Vocal Fold Model Fabrication

Published on: December 2, 2011

Manufacturing Process for Non-Adhesive Super-Soft Vocal Fold Models
06:24

Manufacturing Process for Non-Adhesive Super-Soft Vocal Fold Models

Published on: January 5, 2024

  • Mechanical properties (elastic modulus) were measured via indentation; collagen deposition was assessed immunohistochemically.

    • Main Results:

    • Bilayered constructs exhibited an indentation modulus (6.8 kPa) comparable to human vocal fold covers.
    • Collagen deposition was observed within the middle of the bilayered constructs.
    • A unilateral vocal fold cover replacement in an excised larynx model demonstrated functional vibration and mucosal waves.

    Conclusions:

    • Bilayered tissue-engineered vocal fold cover replacements possess mechanical properties and microstructure similar to native human vocal fold covers.
    • These constructs exhibit functional vibration, indicating their potential for restoring voice function.
    • Tissue engineering provides a viable strategy for developing replacements for damaged vocal fold covers.