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A novel HLA-B allele, B*5535, was identified by sequence-based typing in a Chinese individual

Y-L Zhuang1, Y-H Song, Y Zhang

  • 1HLA Typing Laboratory, Blood Center of Shandong Province, Jinan, China. zhuchuanfu2008@tom.com

Tissue Antigens
|March 4, 2010
PubMed

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...