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Updated: Jun 15, 2026
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
Bone marrow micrometastases studied by an immunomagnetic isolation procedure in extremity localized non-metastatic
Øyvind S Bruland1, Hanne Høifødt, Kirsten Sundby Hall
1Faculty of Medicine, University of Oslo and Department of Oncology, The Norwegian Radium Hospital, N-0310, Oslo, Norway. oyvind.bruland@medisin.uio.no
Abstract:
Hematogenous spread of tumor cells is an early event in osteosarcoma and present in the majority of patients at primary diagnosis. Eradication of such micrometastases by adjuvant combination chemotherapy is crucial for survival. However, a survival plateau of 60-70% was reached over two decades ago, above which it seems difficult to further advance with the currently available therapies. In this study we have, by an immunomagnetic isolation procedure, examined the presence and prognostic impact of disseminated tumor cells in bone marrow aspirates taken at primary diagnosis in a cohort of 41 non-metastatic patients with extremity localized, high-grade osteosarcoma.
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