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Related Concept Videos

Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Suctioning the Oropharyngeal Airway01:25

Suctioning the Oropharyngeal Airway

In preparing for oropharyngeal airway suctioning, a nurse must gather all necessary equipment, including a suction unit with tubing, a prepackaged suction kit, sterile gloves, water or saline for irrigation, a water-soluble lubricant, and additional personal protective equipment (such as a gown, mask, and goggles) to control infections.
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Oral Cavity01:11

Oral Cavity

The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
Drugs in...
Assessment of the Mouth01:26

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.

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Related Experiment Video

Updated: Jun 15, 2026

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope
13:50

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope

Published on: June 17, 2025

Improving oral delivery.

Franz Gabor1, Christian Fillafer, Lukas Neutsch

  • 1Department of Pharmaceutical Technology and Biopharmaceutics, Universität Wien, Althanstrasse 14, A-1090, Vienna, Austria.

Handbook of Experimental Pharmacology
|March 11, 2010
PubMed
Summary
This summary is machine-generated.

Oral drug delivery, comprising 90% of medicines, faces challenges due to biopharmaceutical factors. Optimizing drug properties and delivery systems enhances oral bioavailability, with future focus on biotech drug administration.

Related Experiment Videos

Last Updated: Jun 15, 2026

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope
13:50

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope

Published on: June 17, 2025

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biopharmaceutics

Background:

  • Oral formulations dominate the pharmaceutical market, accounting for an estimated 90% of all medicines due to patient, industry, and healthcare system advantages.
  • Despite widespread use, oral drug delivery presents significant challenges related to the physicochemical properties of drugs and the physiological environment of the gastrointestinal tract.

Purpose of the Study:

  • To explore the key parameters influencing oral drug delivery.
  • To discuss strategies for overcoming challenges in oral drug formulation.
  • To highlight future directions in oral drug delivery, including the administration of biotech drugs.

Main Methods:

  • Analysis of biopharmaceutical factors affecting oral drug absorption.
  • Identification of critical physicochemical and physiological parameters (solubility, permeability, residence time).
  • Review of drug and delivery system characteristics that can be modified (size, pH, diffusion, adhesion, degradation).

Main Results:

  • Solubility, permeability, and gastrointestinal residence time are identified as critical parameters for successful oral drug delivery.
  • Adjusting drug and delivery system characteristics such as particle size, pH, density, diffusion, swelling, adhesion, and degradation can significantly improve oral bioavailability.
  • Biopharmaceutical considerations are paramount in optimizing oral drug formulations.

Conclusions:

  • Oral drug delivery, while prevalent, requires careful management of biopharmaceutical challenges.
  • Tailoring drug and delivery system properties is essential for enhancing oral bioavailability.
  • Future research aims to improve patient compliance and enable oral delivery of complex biologics.