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Nonpeptide angiotensin II receptor antagonists
P B Timmermans1, P C Wong, A T Chiu
1Du Pont Merck Pharmaceutical Co., Wilmington, DE 19880-0400.
Trends in Pharmacological Sciences
|February 1, 1991
Summary
Researchers have developed nonpeptide angiotensin II receptor antagonists, offering new therapeutic options. These compounds are crucial for studying angiotensin II
Area of Science:
- Pharmacology
- Medicinal Chemistry
Background:
- Development of nonpeptide angiotensin II receptor antagonists was a significant challenge.
- Angiotensin II plays a critical role in various physiological processes.
Purpose of the Study:
- To review the pharmacology and development of nonpeptide angiotensin II receptor antagonists.
- To highlight the identification of DuP753 as a lead compound and clinical candidate.
Main Methods:
- Review of pharmacological data.
- Analysis of the discovery process for angiotensin II receptor antagonists.
Main Results:
- Substantial progress has been made in developing nonpeptide angiotensin II receptor antagonists.
- DuP753 has been identified as a promising clinical candidate.
- These antagonists serve as valuable tools for research.
Conclusions:
- Nonpeptide angiotensin II receptor antagonists are novel therapeutic agents.
- These compounds aid in exploring the roles of angiotensin II.
- Evidence suggests the existence of multiple angiotensin II binding sites/receptors.