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Related Concept Videos

Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Nervous Tissue: Neuron Types01:19

Nervous Tissue: Neuron Types

Neurons, the fundamental units of the nervous system, can be classified based on both their structural and functional characteristics.
Structurally, neurons are categorized into three main types: multipolar, bipolar, and unipolar (or pseudounipolar). Multipolar neurons, which are the most common type in the brain and spinal cord, as well as all motor neurons, possess multiple dendrites and a single axon.
Bipolar neurons, on the other hand, have one primary dendrite and one axon. They are...

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Articles linked to this work by shared authors, journal, and citation graph.

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Binucleated and Multinucleated Neurons are Formed by Fusion.

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Related Experiment Video

Updated: Jun 14, 2026

A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening
05:29

A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening

Published on: October 6, 2014

[Neuronal division or enucleation].

O S Sotnikov, A A Laktionova, I A Solov'eva

    Morfologiia (Saint Petersburg, Russia)
    |April 3, 2010
    PubMed
    Summary

    Morphological phenomena previously thought to be neuron division are actually caused by nucleus displacement. This study suggests these changes result from actin microfilament inhibition, impacting cytoskeleton stability.

    Area of Science:

    • Neurobiology
    • Cell Biology

    Context:

    • Classical neurohistological methods have produced images interpreted as neuron division, budding, and fission.
    • These phenomena have been observed under various experimental conditions and in different cell types.

    Purpose:

    • To investigate the morphological changes in neurons previously interpreted as division.
    • To determine if these changes are related to cytoskeleton dynamics and nucleus displacement.

    Summary:

    • Isolated mollusk neurons treated with cytochalasin B (an actin microfilament inhibitor) exhibited nucleus displacement, ectopy, and bulging, mimicking previously reported signs of neuron division.
    • Time-lapse video recording confirmed these dynamic changes, including nucleus displacement and near-complete fission of the neuronal body.
    • Control experiments with dimethyl sulfoxide solvent showed no such effects, supporting cytochalasin B's role.

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    Last Updated: Jun 14, 2026

    A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening
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    A Highly Reproducible and Straightforward Method to Perform In Vivo Ocular Enucleation in the Mouse after Eye Opening

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    Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro

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    Impact:

    • Challenges the long-held interpretation of certain morphological changes as true neuron division.
    • Proposes a new explanation involving actin microfilament inhibition and its effect on the cytoskeleton and nucleus positioning.
    • Suggests spontaneous cytoskeleton instability may underlie these phenomena in metabolically stressed cells.