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The effect of nanotubular titanium surfaces on osteoblast differentiation
Jae-Hyung Kim1, Kwan-Pyo Cho, Young-Suk Chung
1Dental Research Institute, School of Dentistry, 2nd Stage of Brain Korea 21 Project, Chonnam National University, Gwangju 500-757, Korea.
Abstract:
The biological response of fetal rat calvarial cells on a TiO2 nanotubular surface (Ti-NT) was evaluated by cell viability assay, alkaline phosphatase (ALP) activity and reverse transcription polymerase chain reaction (RT-PCR) analysis. The cell viability assay showed no significant difference between the Ti-NT and smooth titanium surfaces (Ti-S). Ti-NT had better cellular responses with regard to the ALP activity and bone-associated markers, such as bone sialoprotein and osteocalcin mRNA than Ti-S. These results suggest that Ti-NT stimulate the differentiation into osteoblasts of fetal rat calvarial cells, potentially contributing to rapid osseointegration.
