Related Experiment Video

Updated: Jun 14, 2026

Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions
12:23

Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions

Published on: October 13, 2015

[Variability of the INV gene fragment encoding a functionally important domain of Yersinia pseudotuberculosis

R R Adgamov, N F Timchenko, A V Allenov

    Molekuliarnaia Genetika, Mikrobiologiia I Virusologiia
    |April 6, 2010
    PubMed

    Insights

    This study analyzed Yersinia pseudotuberculosis inv gene alleles in Russian isolates. Allele 1 was most common overall, but allele distribution differed significantly between clinical and wild rodent Y. pseudotuberculosis isolates.

    Area of Science:

    • Microbiology
    • Genetics
    • Epidemiology

    Context:

    • Yersinia pseudotuberculosis is a significant human pathogen causing pseudotuberculosis and Far East scarlet-like fever.
    • Understanding the genetic diversity of Y. pseudotuberculosis is crucial for tracking outbreaks and disease transmission.
    • This study focuses on isolates collected in the Russian Federation between 1967 and 2008.

    Purpose:

    • To investigate the allelic variations within a specific fragment of the Y. pseudotuberculosis inv gene.
    • To determine the distribution of these inv gene alleles among different Y. pseudotuberculosis subpopulations based on origin (clinical, environmental, wild rodents) and serovar.
    • To analyze potential correlations between inv gene allelic variants and the source of Y. pseudotuberculosis isolation.

    Summary:

    • Eighty-four Yersinia pseudotuberculosis isolates from the Russian Federation were analyzed for variations in a 600 bp fragment of the inv gene.
    • Three distinct allelic variants were identified, with allele 1 being the most prevalent (76 isolates).
    • A statistically significant difference was observed in allele distribution between clinical isolates (95% allele 1) and wild rodent isolates (55% allele 1, 45% allele 2).

    Impact:

    • The findings highlight a significant genetic differentiation in Y. pseudotuberculosis populations based on their isolation source, suggesting distinct evolutionary or epidemiological trajectories.
    • This research contributes to a deeper understanding of Y. pseudotuberculosis population structure and the genetic factors influencing its epidemiology.
    • The study provides valuable data for future epidemiological surveillance and the development of targeted control strategies for Yersinia pseudotuberculosis infections.

    More Related Videos

    Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth08:36

    Quantifying Yersinia pseudotuberculosis Type III Secretion System Activity Following Iron Starvation and Anaerobic Growth

    Published on: May 31, 2024

    Quantitative Measurement of Invadopodia-mediated Extracellular Matrix Proteolysis in Single and Multicellular Contexts14:23

    Quantitative Measurement of Invadopodia-mediated Extracellular Matrix Proteolysis in Single and Multicellular Contexts

    Published on: August 27, 2012

    Related Concept Videos

    Cancer Cell Migration through Invadopodia01:35

    Cancer Cell Migration through Invadopodia

    Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
    Determinants of Bacterial Pathogenicity and Virulence01:20

    Determinants of Bacterial Pathogenicity and Virulence

    Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
    Exon Recombination02:32

    Exon Recombination

    The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
    Exon shuffling follows “splice frame rules.” Each exon has three reading...
    Regulation of Bacterial Virulence01:28

    Regulation of Bacterial Virulence

    Pathogenic bacteria employ a range of regulatory mechanisms to modulate the expression of virulence genes in response to environmental and host-derived signals. These mechanisms ensure that virulence factors are expressed only under favorable conditions, thereby optimizing infection and survival strategies.Mechanisms of Virulence RegulationKey regulatory strategies include:Two-Component Systems: These consist of a membrane-bound sensor kinase and a cytoplasmic response regulator. Environmental...
    Plague01:24

    Plague

    Plague is a highly virulent zoonotic disease caused by Yersinia pestis, a Gram-negative, facultatively anaerobic coccobacillus. This pathogen primarily circulates among rodent populations and is transmitted to humans through the bite of infected fleas. Additional transmission routes include direct contact with infected animal tissue or inhalation of respiratory droplets from individuals with pneumonic plague. These multiple transmission pathways highlight the bacterium’s potential for rapid...
    Protein Complexes with Interchangeable Parts01:57

    Protein Complexes with Interchangeable Parts

    Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
    The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...