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Telebrix: a better-tasting oral contrast agent for abdominal computed tomography
1Department of Diagnostic Radiology and Nuclear Medicine, University Hospital, University of Western Ontario, London.
Summary
Telebrix 38 (ioxithalamate) offers superior taste and patient tolerance compared to Gastrografin (diatrizoate) for computed tomography (CT) abdominal imaging. Both contrast agents provide excellent bowel opacification, but Telebrix 38 enhances patient experience during CT scans.
Area of Science:
- Radiology
- Medical Imaging
- Gastroenterology
Background:
- Contrast agents are crucial for enhancing visualization in computed tomography (CT).
- Patient tolerance and taste perception can impact adherence to oral contrast administration.
Purpose of the Study:
- To compare Telebrix 38 (ioxithalamate) and Gastrografin (diatrizoate) for abdominal and pelvic CT.
- To evaluate taste, patient tolerance, and bowel opacification efficacy of these two oral contrast agents.
Main Methods:
- A randomized, controlled, double-blind trial was conducted.
- Patients received either Telebrix 38 or Gastrografin (2% solutions) for bowel opacification in CT scans.
- Taste, willingness to re-ingest, and side effects were assessed.
Main Results:
- Both Telebrix 38 and Gastrografin provided excellent bowel opacification.
- Patients rated Telebrix 38 significantly better in taste than Gastrografin (89% vs. 59% excellent/good taste).
- Telebrix 38 showed better patient tolerance, with fewer patients unwilling to drink it again.
Conclusions:
- Telebrix 38 is preferable to Gastrografin for oral contrast in abdominal/pelvic CT due to improved taste and patient tolerance.
- Telebrix 38 achieves equivalent excellent bowel opacification as Gastrografin.
- Enhanced patient experience with Telebrix 38 may improve compliance in CT imaging procedures.