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Updated: Jun 13, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
[Celiac disease--a diagnostic and therapeutic challenge]
Katri Kaukinen1, Pekka Collin, Markku Mäki
1Tampereen yliopisto, lääketieteen laitos, 33014 Tampereen yliopisto ja TAYS, gastroenterologian vastuualue.
Celiac disease affects over 2% of Finnish adults. Early detection using antibody tests can identify developing cases before intestinal damage occurs, enabling management through a gluten-free diet.
Area of Science:
- Gastroenterology
- Immunology
- Epidemiology
Context:
- Celiac disease prevalence in Finland exceeds 2% in adults.
- Diagnosis traditionally relies on biopsy-confirmed villous atrophy.
- Disease onset can precede observable intestinal damage.
Purpose:
- To highlight the utility of sensitive antibody tests for early celiac disease detection.
- To emphasize the significance of identifying developing celiac disease.
- To underscore the importance of early diagnosis and management.
Summary:
- Sensitive antibody tests (anti-endomysium, anti-tissue transglutaminase) can detect celiac disease precursors.
- Elevated antibodies with normal villi suggest developing celiac disease.
- A strict gluten-free diet maintains asymptomatic status and functionality.
Impact:
- Facilitates earlier diagnosis and intervention for celiac disease.
- Reduces the risk of long-term complications associated with untreated celiac disease.
- Improves patient quality of life through sustained health and productivity.
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