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Strategies for Assessing Autistic-Like Behaviors in Mice
Published on: September 20, 2024
[Evolution of the concept of autism]
1Service de psychiatrie de l'enfant et de l'adolescent, hôpital Necker-Enfants malades, AP-HP, 75015 Paris. laurence.robel@nck.aphp.fr
Abstract:
Since it was originally described in 1943 by L. Kanner, the concept of autism has changed. Autistic disorder is now recognized as a pervasive developmental disorder diagnosed on the basis of three behaviorally altered domains: social deficits, impaired language and communication, and stereotyped and repetitive behaviors. The prevalence of the autistic disorder according to these criteria has raised to about 0.3%, and the prevalence of the pervasive developmental disorders is estimated between 0.3 and 0.6%. Autism is now considered as an heterogeneous neurodevelopmental syndrome, with genetic and environmental factors contribution.
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