An excellent enzyme biosensor based on Sb-doped SnO2 nanowires

Area of Science:

• Nanoscience and Nanotechnology
• Biosensor Development
• Materials Science

Background:

• Tin oxide (SnO2) is a semiconductor with potential applications in biosensing.
• Developing efficient immobilization matrices is crucial for high-performance biosensors.
• Mediator-free biosensors offer advantages in simplicity and reduced cost.

Purpose of the Study:

• To synthesize and characterize antimony-doped tin oxide (Sb-doped SnO2) nanowires.
• To investigate the utility of Sb-doped SnO2 nanowires as an immobilization matrix for enzymes in a biosensor.
• To evaluate the performance of a mediator-free hydrogen peroxide (H2O2) biosensor utilizing Sb-doped SnO2 nanowires.

Main Methods:

• Synthesis of Sb-doped SnO2 nanowires via thermal evaporation.
• Characterization using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD).
• Fabrication and electrochemical testing (current-voltage, electrochemical impedance spectroscopy) of a horseradish peroxidase (HRP)-based H2O2 biosensor.

Main Results:

• Sb-doped SnO2 nanowires exhibited enhanced electron transfer properties and electroactivity compared to undoped SnO2.
• The fabricated biosensor demonstrated high sensitivity, a wide linear range, and excellent long-term stability.
• Enhanced carrier density due to Sb doping and the biocompatible microenvironment contributed to improved biosensor performance.

Conclusions:

• Sb-doped SnO2 nanowires serve as a promising platform for constructing efficient mediator-free biosensors.
• The study provides fundamental insights into nanoscience and nanodevice applications.
• Antimony doping significantly enhances the performance of SnO2-based biosensors for H2O2 detection.