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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Hemoglobin01:24

Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

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Related Experiment Video

Updated: Jun 13, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Hemobilia.

Marcus W Chin1, Robert Enns

  • 1University of Western Australia, St Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada. marcuschinau@yahoo.com.au

Current Gastroenterology Reports
|April 29, 2010
PubMed
Summary
This summary is machine-generated.

Hemobilia, or bleeding into the bile ducts, is uncommon but increasingly iatrogenic. Diagnosis involves considering upper GI bleeding in patients with jaundice, pain, and a history of liver procedures or trauma.

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Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
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Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

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Blood Collection from the American Horseshoe Crab, Limulus Polyphemus
12:48

Blood Collection from the American Horseshoe Crab, Limulus Polyphemus

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Related Experiment Videos

Last Updated: Jun 13, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis
11:50

Ex vivo Mimicry of Normal and Abnormal Human Hematopoiesis

Published on: April 10, 2012

Blood Collection from the American Horseshoe Crab, Limulus Polyphemus
12:48

Blood Collection from the American Horseshoe Crab, Limulus Polyphemus

Published on: October 13, 2008

Area of Science:

  • Hepatology
  • Gastroenterology
  • Interventional Radiology

Background:

  • Hemobilia is a rare condition with diverse presentations.
  • Iatrogenic causes are becoming more frequent.
  • Diagnosis is crucial in specific patient populations.

Purpose of the Study:

  • To review the diagnostic and management strategies for hemobilia.
  • To highlight the importance of considering hemobilia in at-risk patients.

Main Methods:

  • Literature review of hemobilia cases and management.
  • Analysis of diagnostic modalities, including multislice computed tomographic angiography.
  • Evaluation of interventional and surgical treatment outcomes.

Main Results:

  • Hemobilia should be suspected in patients with upper gastrointestinal bleeding, jaundice, abdominal pain, and a history of percutaneous liver intervention or trauma.
  • Multislice computed tomographic angiography is a key diagnostic tool.
  • Transcatheter arterial embolization is the primary intervention for significant hemobilia.

Conclusions:

  • Most hemobilia cases can be managed non-surgically through supportive care or interventional radiology.
  • Surgical intervention is rarely required for hemobilia management.