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The cooperative roles of Foxc1 and Foxc2 in cardiovascular development

Tsutomu Kume1

  • 1Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Ave, Nashville, Tennessee 37232-6300, USA. tsutomu.kume@vanderbilt.edu

Advances in Experimental Medicine and Biology
|May 1, 2010
PubMed

Insights

Foxc1 and Foxc2 transcription factors are crucial for cardiovascular development, cooperating in a dose-dependent manner to regulate arterial cell specification and lymphatic vessel formation.

Area of Science:

  • Developmental Biology
  • Molecular Genetics
  • Cardiovascular Research

Background:

  • Foxc1 and Foxc2 are related Forkhead/Fox transcription factors with overlapping expression patterns.
  • Both genes regulate similar developmental processes and show similar phenotypes in mouse mutants.
  • Previous studies suggest their importance in embryonic development, including the eye, kidney, and cardiovascular system.

Purpose of the Study:

  • To summarize and discuss the current understanding of Foxc1 and Foxc2 functions in cardiovascular development.
  • To highlight their roles in specific cardiovascular processes such as arterial specification and lymphatic development.

Main Methods:

  • Analysis of compound Foxc1; Foxc2 mutant mouse embryos.
  • Review of recent studies on the functions of Foxc1 and Foxc2 in development.

Main Results:

  • Foxc1 and Foxc2 exhibit dose-dependent and cooperative roles in embryonic development.
  • These transcription factors are essential for arterial cell specification.
  • They play critical roles in lymphatic vessel formation, angiogenesis, and cardiac outflow tract development.

Conclusions:

  • Foxc1 and Foxc2 are indispensable for normal cardiovascular development.
  • Their cooperative and dose-dependent functions underscore their significance in vascular morphogenesis.

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