Related Experiment Video
Updated: Jun 13, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
Published on: March 24, 2017
The forkhead transcription factors play important roles in vascular pathology and immunology
Xiao-Feng Yang1, Pu Fang, Shu Meng
1Department of Pharmacology, Cardiovascular Research Center, Temple University School of Medicine, 3420 North Broad Street, MRB, Rm 325, Philadelphia, Pennsylvania 19140, USA. xfyang@temple.edu
Abstract:
Transcription factor families are a small number of upstream master genes in "higher hierarchy" that control the expression of a large number of downstream genes. These transcription factors have been found to integrate the signaling pathways underlying the pathogenesis of cardiovascular diseases with or without autoimmune inflammatory mechanisms. In this chapter, we organize our analysis of recent progress in characterization of forkhead (Fox) transcription factor family members in vascular pathology and immune regulation into the following sections: (1) Introduction of the FOX transcription factor superfamily; (2) FOX transcription factors and endotheial cell pathology; (3) FOX transcription factors and vascular smooth muscle cells; and (4) FOX transcription factors, inflammation and immune system. Advances in these areas suggest that the FOX transcription factor family is important in regulating vascular development and the pathogenesis of autoimmune inflammatory cardiovascular diseases.
More Related Videos
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
General Transcription Factors
Transcription Factors
Transcription Factors
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-kB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
