Related Experiment Video
Updated: Jun 13, 2026

Three-Dimensional Cephalometric Landmark Annotation Demonstration on Human Cone Beam Computed Tomography Scans
Published on: September 8, 2023
Concomitant presentation of three rare mesencephalic syndromes: case report
Sandeep Randhawa1, Megan M Donohue, Steven R Hamilton
1Department of Ophthalmology, University of Washington, Seattle, WA, USA. drsrandhawa@gmail.com
This case report details a rare instance of three mesencephalic syndromes occurring together after a stroke. Neuro-ophthalmic examination and MRI confirmed the diagnosis, highlighting ocular motility
Area of Science:
- Neurology
- Neuro-ophthalmology
Background:
- Mesencephalic syndromes are rare neurological conditions affecting the midbrain.
- Concomitant occurrence of multiple mesencephalic syndromes is exceptionally uncommon.
Observation:
- A 48-year-old male presented with an acute stroke.
- Neuro-ophthalmic evaluation revealed a unique combination of plus-minus lid syndrome, vertical one-and-a-half syndrome, and Claude's syndrome.
Findings:
- Magnetic resonance imaging (MRI) confirmed infarction at the thalamo-mesencephalic junction and right rostral midbrain.
- Lesions involved the third nerve fascicle and red nucleus, correlating with the observed syndromes.
Implications:
- This case underscores the diagnostic value of detailed ocular motility examination in localizing midbrain strokes.
- Recognizing combined mesencephalic syndromes aids in precise anatomical diagnosis and patient management.
More Related Videos
08:03Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
08:22A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
Published on: December 1, 2017
Related Concept Videos
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Epilepsy ll: Types
Encephalitis l: Introduction
Aneurysm II: Clinical Manifestations and Diagnostic Studies