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Retzius-Sparing Robot-Assisted Radical Prostatectomy
Published on: May 19, 2022
[Case of persistent false elevation of prostate-specific antigen after radical prostatectomy]
Yohei Shida1, Yushi Imasato, Toshifumi Tsurusaki
1Department of Urology, Kamigoto Hospital.
Hinyokika Kiyo. Acta Urologica Japonica
|May 8, 2010
Summary
Persistent false elevation of prostate-specific antigen (PSA) after radical prostatectomy (RP) is rare. Despite hormone therapy and negative imaging, PSA levels remained elevated, indicating assay interference rather than recurrence.
Area of Science:
- Urology
- Oncology
- Clinical Chemistry
Background:
- Radical prostatectomy (RP) is a primary treatment for prostate cancer.
- Postoperative monitoring typically involves prostate-specific antigen (PSA) testing.
- Persistent PSA elevation after RP can indicate recurrence or other factors.
Observation:
- A patient presented with persistently elevated PSA post-RP.
- Initial pathology revealed Gleason score 8, pT3aN0M0.
- PSA levels remained elevated despite 10 months of adjuvant hormone therapy.
Findings:
- Imaging studies for metastasis were negative, ruling out recurrence.
- Subsequent PSA assays consistently showed unmeasurable levels.
- This suggests a rare case of persistent false PSA elevation.
Implications:
- Assay interference should be considered in cases of unexplained PSA elevation post-prostatectomy.
- Further investigation into PSA assay methodologies may be warranted.
- Accurate PSA monitoring is crucial for effective prostate cancer management.
