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Updated: Jun 12, 2026
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Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
Vitamin D and fracture prevention
1Centre on Aging and Mobility, University of Zurich, Zurich, Switzerland. Heike.Bischoff@usz.ch
Summary
This study explores optimal vitamin D supplementation levels and target 25-hydroxyvitamin D concentrations for effective fracture prevention in adults. Achieving adequate vitamin D status is key to bone health.
Area of Science:
- Endocrinology
- Bone Metabolism
- Nutritional Science
Background:
- Vitamin D plays a crucial role in calcium homeostasis and bone health.
- Vitamin D deficiency is prevalent and associated with increased fracture risk.
- Optimal serum concentrations of 25-hydroxyvitamin D for bone health are debated.
Purpose of the Study:
- To determine the necessary vitamin D supplementation dosage for achieving target serum levels.
- To identify the desirable 25-hydroxyvitamin D level for optimal fracture prevention.
- To provide evidence-based recommendations for vitamin D intake.
Main Methods:
- Literature review of studies on vitamin D supplementation and bone health.
- Analysis of dose-response relationships between vitamin D intake and serum 25-hydroxyvitamin D levels.
- Meta-analysis of randomized controlled trials investigating vitamin D and fracture incidence.
Main Results:
- Specific daily or weekly dosages of vitamin D supplementation are identified to reach target 25-hydroxyvitamin D levels.
- A target range for serum 25-hydroxyvitamin D is proposed for maximizing fracture prevention benefits.
- Individual variability in response to supplementation is acknowledged.
Conclusions:
- Adequate vitamin D supplementation is essential for maintaining bone integrity and reducing fracture risk.
- Achieving and maintaining a specific 25-hydroxyvitamin D level is critical for skeletal health.
- Personalized approaches to vitamin D supplementation may be warranted based on individual factors.
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