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Programmed Electrical Stimulation in Mice
Published on: May 26, 2010
Programmed electrical stimulation in mice
1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, USA.
Journal of Visualized Experiments : Jove
|June 1, 2010
Summary
Genetically-modified mice enable studying cardiac conduction abnormalities and arrhythmias. Programmed electrical stimulation in mice offers insights into molecular mechanisms of sudden cardiac death.
Area of Science:
- Cardiology
- Molecular Biology
- Animal Models
Background:
- Genetically-modified mice are valuable for studying cardiac electrophysiology.
- Understanding conduction abnormalities and arrhythmias is crucial for preventing sudden cardiac death.
Purpose of the Study:
- To detail the methodology for programmed electrical stimulation in mice.
- To highlight the utility of this model for investigating cardiac arrhythmias.
Main Methods:
- Utilizing a 1.1F octapolar catheter inserted via the jugular vein into the right atrium and ventricle.
- Simultaneous recording of surface ECG and intracardiac electrograms.
- Performing atrial pacing with an external stimulator.
Main Results:
- Demonstrated feasibility of programmed electrical stimulation in mice.
- Enabled simultaneous recording of cardiac electrical activity from multiple sites.
- Provided a platform for investigating molecular mechanisms of arrhythmias.
Conclusions:
- Programmed electrical stimulation in mice is an effective technique.
- This model system offers unique opportunities to study molecular underpinnings of cardiac conduction defects and arrhythmias.
- Facilitates research into sudden cardiac death mechanisms.
