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07:15
Anaerobic Growth and Maintenance of Mammalian Cell Lines
Published on: July 21, 2018
Perspectives in cell cycle regulation: lessons from an anoxic vertebrate
Kyle K Biggar1, Kenneth B Storey
1Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada.
Current Genomics
|June 2, 2010
Summary
Anoxia-tolerant turtles can survive oxygen deprivation by reducing ATP consumption. This review explores how their cell cycle control, particularly the retinoblastoma pathway, enables survival during anoxia.
Area of Science:
- Biochemistry
- Cell Biology
- Comparative Physiology
Background:
- Animals surviving anoxia undergo significant physiological and biochemical changes to reduce ATP consumption.
- Anoxia-tolerant vertebrates, like turtles, employ strategies such as metabolic depression, post-translational modifications, and gene expression controls.
- The cell cycle state during anoxia in adult vertebrates remains largely uncharacterized, unlike in invertebrates and embryonic models.
Purpose of the Study:
- To review the mechanisms of cell cycle arrest in anoxia-tolerant vertebrates.
- To investigate the control of the retinoblastoma pathway during anoxic conditions.
- To explore molecular markers, checkpoint kinases, and microRNA involvement in anoxic cell cycle regulation.
Main Methods:
- This review synthesizes existing literature on anoxia tolerance and cell cycle regulation.
- It discusses theoretical models of cell cycle arrest in anoxic vertebrates.
- Focuses on specific molecular pathways including the retinoblastoma pathway and microRNA regulation.
Main Results:
- Anoxia tolerance involves metabolic suppression and controlled ATP reduction.
- Cell cycle arrest is a known response to anoxia in some species.
- The retinoblastoma pathway and microRNAs are potential regulators of cell cycle arrest in anoxic turtles.
Conclusions:
- Understanding anoxic cell cycle control in turtles has implications for cancer research, specifically hypoxic tumor progression.
- Further characterization of the cell cycle in anoxia-tolerant turtles is needed.
- Molecular mechanisms controlling cell cycle arrest offer therapeutic targets for diseases involving hypoxia.
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