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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

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Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
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Drug delivery to solid tumors by elastin-like polypeptides.

Jonathan R McDaniel1, Daniel J Callahan, Ashutosh Chilkoti

  • 1Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708-0181, USA.

Advanced Drug Delivery Reviews
|June 16, 2010
PubMed
Summary
This summary is machine-generated.

Thermally responsive elastin-like polypeptides (ELPs) offer novel drug delivery strategies for solid tumors. These biopolymers enable targeted delivery and enhanced treatment efficacy by leveraging their unique thermal properties for nanoparticle formation and localized drug release.

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Published on: November 1, 2017

Area of Science:

  • Biotechnology
  • Materials Science
  • Oncology

Background:

  • Elastin-like polypeptides (ELPs) are advanced biopolymers with tunable thermal responsiveness.
  • Their unique transition temperature (Tt) relative to body temperature (Tb) enables diverse applications in drug delivery.
  • Solid tumors present unique challenges for drug delivery due to their microenvironment.

Purpose of the Study:

  • To review four distinct applications of ELPs for drug and imaging agent delivery to solid tumors.
  • To highlight how ELP thermal properties are exploited for targeted delivery and enhanced therapeutic outcomes.
  • To showcase ELPs as versatile platforms for both systemic and local cancer therapy.

Main Methods:

  • Conjugating hydrophobic drugs to ELPs for nanoparticle self-assembly when Tt >> Tb.
  • Utilizing mild hyperthermia with ELP-drug conjugates (Tb < Tt < 42°C) to induce in-situ coacervation.
  • Designing hydrophilic-hydrophobic ELP block copolymers for hyperthermia-triggered nanoparticle assembly and vascular targeting.
  • Developing ELP-radiotherapeutic conjugates (Tt < Tb) for intratumoral injection and depot formation.

Main Results:

  • Systemic ELP-drug nanoparticles exploit the EPR effect for tumor localization, reducing toxicity.
  • External hyperthermia with ELP-drug conjugates increases drug concentration in tumor vasculature.
  • ELP block copolymers form nanoparticles for enhanced vascular targeting via multivalent ligand display.
  • Intratumoral ELP-radiotherapeutic depots provide sustained drug release and inhibit tumor growth.

Conclusions:

  • ELPs offer versatile, tunable platforms for advanced cancer drug delivery.
  • Tailoring ELP transition temperatures enables diverse strategies for targeted therapy.
  • ELP-based approaches demonstrate potential for reduced systemic toxicity and improved treatment efficacy.