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Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues
Published on: June 2, 2023
Engineered heart tissue: high throughput platform for dissection of complex diseases.
Jozef Lazar1, Howard J Jacob, Tetsuro Wakatsuki
1Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jlazar@mcw.edu
Journal of Cardiovascular Translational Research
|June 19, 2010
Summary
The heart
Area of Science:
- Cardiovascular Science
- Genetics
- Biotechnology
Background:
- The genetic basis of heart's response to ischemia is complex and polygenic.
- Identifying specific genes involved in cardiac ischemia response remains challenging.
Purpose of the Study:
- To introduce engineered heart tissue (EHT) as a novel tool.
- To utilize EHT for accelerating positional cloning of relevant genes.
- To develop new functional assays for studying cardiac response to ischemia.
Main Methods:
- Development and application of engineered heart tissue (EHT) models.
- Positional cloning techniques for gene identification.
- Functional assays to assess cardiac response.
Main Results:
- Engineered heart tissue (EHT) provides a platform for gene discovery.
- EHT facilitates the development of new functional assays for cardiac ischemia research.
Conclusions:
- Engineered heart tissue (EHT) is a promising tool for understanding the genetic underpinnings of cardiac ischemia.
- This approach accelerates the identification of genes involved in heart's response to ischemic insult.
