On the regulation of DNA methylation by higher-order structure in the cell nucleus

Several years ago it was postulated that DNA methylation may play a role in the regulation of gene activity in animal cells. Progress has been made in establishing the mechanisms by which methylation influences gene expression, but little is known about the mechanisms that control methylation itself. Here is proposed a model, susceptible of experimental confirmation, which suggests that chromatin higher-order structure is a determinant factor for the regulation of DNA methylation. The background for such a model as well as current evidence in support of it are discussed.