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SLT and adjunctive medical therapy: a prediction rule analysis
Evan Martow1, Cindy M L Hutnik, Alexander Mao
1Department of Ophthalmology, Ivey Eye Institute, St Joseph's Hospital, Lawson Health Research Institute, University of Western Ontario, Ontario, Canada.
Journal of Glaucoma
|June 26, 2010
Summary
Selective laser trabeculoplasty (SLT) success is not affected by glaucoma medications. Higher pre-treatment intraocular pressure (IOP) is the key predictor of successful SLT outcomes.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Laser Therapy
Background:
- Selective laser trabeculoplasty (SLT) is a common treatment for open-angle glaucoma and ocular hypertension.
- The influence of pre-existing antiglaucoma medications on SLT success remains an area of investigation.
Purpose of the Study:
- To determine if specific classes of antiglaucoma medications impact the success of selective laser trabeculoplasty (SLT).
- To identify predictors of SLT treatment success.
Main Methods:
- Retrospective analysis of 120 eyes from patients with open-angle glaucoma or ocular hypertension undergoing SLT.
- Treatment success defined as ≥20% intraocular pressure (IOP) reduction at 3 and 6 months post-SLT.
- Multivariate logistic regression used to identify success predictors.
Main Results:
- Pre-treatment intraocular pressure (IOP) was the sole independent predictor of achieving ≥20% IOP reduction (OR=1.30).
- The area under the receiver operator characteristic curve was 0.777, indicating moderate predictive accuracy.
- No significant association found between antiglaucoma medication class and SLT efficacy.
Conclusions:
- Antiglaucoma medications, whether topical or otherwise, do not appear to influence SLT success rates.
- SLT efficacy is positively correlated with the degree of IOP elevation prior to treatment.
- Factors such as anterior chamber pigmentation, diabetes, and previous treatments did not show an association with SLT efficacy.
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