Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine Learning-Driven Simulations of the SARS-CoV-2 Fitness Landscape from Deep Mutational Scanning Experiments.

Journal of chemical information and modeling·2026
Same author

Advancing concussion assessment for para sport athletes through the Para SCAT6 initiative.

British journal of sports medicine·2026
Same author

The Adolescent Athlete and the Team Physician: A Consensus Statement. 2025 Update.

Current sports medicine reports·2026
Same author

Situational awareness predicts self-management of type I diabetes in adolescents and young adults.

Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2026
Same author

The Reversed Palmaris Longus: Sonographic Findings and Anatomical Correlation With Implications for Carpal Tunnel Syndrome Diagnosis and Management.

Journal of hand surgery global online·2026
Same author

The Adolescent Athlete and the Team Physician: A Consensus Statement. 2025 Update.

Medicine and science in sports and exercise·2026
Same journal

"Women's Sports Is Still in its Infancy." - Billie Jean King.

Clinics in sports medicine·2026
Same journal

Treatment Considerations in the Female Athlete.

Clinics in sports medicine·2026
Same journal

Sports Considerations Related to Pregnancy and Postpartum.

Clinics in sports medicine·2026
Same journal

Management of Bone Stress Injuries: A Holistic Approach.

Clinics in sports medicine·2026
Same journal

Relative Energy Deficiency in Sport.

Clinics in sports medicine·2026
Same journal

Gymnastics-Related Injuries for the Female Athlete.

Clinics in sports medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 11, 2026

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
08:26

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

Neuropathies in runners.

Evan Peck1, Jonathan T Finnoff, Jay Smith

  • 1Department of Physical Medicine and Rehabilitation, Mayo Clinic Sports Medicine Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Clinics in Sports Medicine
|July 9, 2010
PubMed
Summary
This summary is machine-generated.

Nerve entrapment can cause lower limb pain in runners. Early diagnosis and management involve a high suspicion for neurological issues, careful examination, and considering various diagnoses for effective treatment.

More Related Videos

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve
07:00

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve

Published on: November 14, 2025

Related Experiment Videos

Last Updated: Jun 11, 2026

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running
08:26

Comparative Analysis of Lower Limb Kinematics between the Initial and Terminal Phase of 5km Treadmill Running

Published on: July 17, 2020

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve
07:00

Novel Surgical Rodent Model for Studying Neuroma Pain Treatment Options using Targeted Muscle Reinnervation Through the Saphenous Nerve

Published on: November 14, 2025

Area of Science:

  • Sports Medicine
  • Neurology
  • Running Injuries

Background:

  • Nerve entrapment is an uncommon cause of lower limb pain in runners.
  • Understanding peripheral nerve involvement is crucial for athletes.

Purpose of the Study:

  • To review the diagnosis and management of nerve entrapment syndromes in runners.
  • To outline key principles for successful clinical application.

Main Methods:

  • Review of common nerve entrapment syndromes affecting runners.
  • Emphasis on clinical examination and diagnostic principles.
  • Integration of neuroanatomy and running biomechanics.

Main Results:

  • Nerve entrapment requires a high index of suspicion and recognition of neuropathic pain.
  • Meticulous physical examination, including postexercise assessment, is vital.
  • A broad differential diagnosis and appropriate use of diagnostic testing are necessary.

Conclusions:

  • Successful management hinges on a systematic approach: suspicion, recognition, examination, differential diagnosis, testing, and rational decision-making.
  • Knowledge of neuroanatomy and running biomechanics enables effective clinical management of nerve entrapment in runners.