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Angiography features of early onset drusen
Benjamin Guigui1, Nicolas Leveziel, Virginie Martinet
1Creteil University Eye Clinic, Créteil, France. esouied@hotmail.com
The British Journal of Ophthalmology
|July 9, 2010
Summary
Early onset drusen (EOD) in patients under 50 are classified into three types using fundus examination and angiography. A new type, large colloid drusen (LCD), shows distinct features and good vision.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Medical Diagnostics
Background:
- Drusen are typically found in older individuals.
- Two known types of early onset drusen (EOD) are basal laminar drusen (BLD) and Malattia Leventinese (ML).
Purpose of the Study:
- To classify the phenotype of early onset drusen (EOD) based on fundus examination, fluorescein angiography (FA), and indocyanine green angiography (ICGA).
Main Methods:
- A prospective study of 48 consecutive EOD patients.
- All patients underwent a comprehensive ophthalmologic examination, including FA and ICGA.
Main Results:
- Basal laminar drusen (BLD) showed extreme hyperfluorescence on FA and ICGA (67%).
- Malattia Leventinese (ML) presented with mixed radial and round drusen, with varied staining on FA and ICGA (10%).
- A third type, large colloid drusen (LCD), exhibited mild early hyperfluorescence on FA and specific hypo/hyperfluorescent patterns on ICGA (23%).
Conclusions:
- Three distinct types of EOD are identifiable through FA and ICGA.
- Large colloid drusen (LCD) represent a newly identified form of juvenile drusen, separate from BLD and ML.
- LCD is associated with preserved visual acuity and no observed complications.
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