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Influence of glycemic control on the development of diabetic cardiovascular and kidney disease
Sandeep A Saha1, Katherine R Tuttle
1Providence Medical Research Center, Spokane, WA 99204, USA. sahas@uw.edu
Abstract:
Diabetes mellitus leads to the development of a host of micro- and macrovascular complications, which collectively lead to substantial morbidity and mortality. Among the microvascular complications of diabetes, diabetic kidney disease is the most common. Macrovascular complications from diabetes lead to a 2- to 4-fold increase in the incidence of cardiovascular disease and up to twice the mortality from cardiovascular causes as compared with nondiabetic individuals. This article discusses the various drug classes used to treat diabetes mellitus, and reviews the current clinical evidence linking glycemic control using these drug classes on diabetic kidney and cardiovascular disease.
Insights
Diabetes mellitus causes serious kidney and cardiovascular complications. This review examines how diabetes medications impact these conditions by controlling blood sugar levels.
Area of Science:
- Endocrinology
- Nephrology
- Cardiology
Background:
- Diabetes mellitus is a chronic condition associated with significant microvascular and macrovascular complications.
- Diabetic kidney disease is the most prevalent microvascular complication.
- Diabetes increases cardiovascular disease incidence and mortality risk.
Purpose of the Study:
- To discuss drug classes for diabetes mellitus management.
- To review clinical evidence on glycemic control's impact on diabetic kidney and cardiovascular disease.
Main Methods:
- Literature review of clinical evidence.
- Analysis of drug classes used in diabetes treatment.
Main Results:
- Glycemic control is crucial for mitigating diabetic complications.
- Different drug classes may have varying effects on kidney and cardiovascular outcomes.
Conclusions:
- Effective management of diabetes mellitus is essential to prevent severe complications.
- Further research is needed to optimize therapeutic strategies for diabetic kidney and cardiovascular disease.
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