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Updated: Jun 10, 2026

Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
Published on: December 30, 2025
Toxoplasmosis, parvovirus, and cytomegalovirus in pregnancy
Deborah M Feldman1, Diane Timms, Adam F Borgida
1Prenatal Testing Center, Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Connecticut School of Medicine, Hartford Hospital, 85 Jefferson Street, Hartford, CT 06102, USA.
Abstract:
Several infections in adults warrant special consideration in pregnant women given the potential fetal consequences. Among these are toxoplasmosis, parvovirus B19, and cytomegalovirus. These infections have an important effect on the developing fetus depending on the timing of infection. This article reviews the modes of transmission as well as maternal and neonatal effects of each of these infections. In addition, recommended testing, fetal surveillance, and treatment where indicated are outlined.
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