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Ex vivo Culture of Human Placental Explants for the Study of Viral Transmission Across the Maternal-Fetal Interface
Published on: December 30, 2025
Toxoplasmosis, Parvovirus, and Cytomegalovirus in Pregnancy
Deborah M Feldman1, Rebecca Keller2, Adam F Borgida1
1Division of Maternal Fetal Medicine, Prenatal Testing Center, Hartford Hospital, University of Connecticut School of Medicine, 85 Jefferson Street, #625, Farmington, CT 06102, USA.
Abstract:
There are several infections in adults that warrant special consideration in pregnant women given the potential fetal consequences. Among these are toxoplasmosis, parvovirus B19, and cytomegalovirus. These infections have an important impact on the developing fetus, depending on the timing of infection. This article reviews the modes of transmission as well as maternal and neonatal effects of each of these infections. In addition, the article outlines recommended testing, fetal surveillance, and treatment where indicated.
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