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Updated: Jun 10, 2026
12:19
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
[The metallic profile: a new biological concept].
Jean-Pierre Goullé1, Elodie Saussereau, Loïc Mahieu
1Laboratoire de pharmacocinétique et de toxicologie cliniques, Groupe hospitalier, Le Havre. jean-pierre.goulle@ch-havre.fr
Annales De Biologie Clinique
|July 24, 2010
Summary
Inductively coupled plasma mass spectrometry (ICP-MS) offers sensitive multi-elemental analysis in biological samples for toxicity assessment. This advanced technique provides a comprehensive metallic profile for diverse clinical and environmental applications.
Area of Science:
- Analytical Chemistry
- Biochemistry
Context:
- Metals and metalloids analysis is crucial for assessing deficiencies and toxicity.
- Atomic absorption spectroscopy is being superseded by more advanced techniques.
Purpose:
- To highlight the capabilities of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in biological and clinical analysis.
- To introduce the concept of a "metallic profile" for comprehensive toxicological assessment.
Summary:
- Inductively Coupled Plasma Mass Spectrometry (ICP-MS) enables sensitive multi-elemental analysis across the periodic table in biological matrices like blood, plasma, urine, hair, and tissue.
- The method allows for the semi-quantitative determination of an additional thirty elements, aiding in the estimation of toxic levels and metal exposure.
- ICP-MS facilitates a novel biological approach, offering a "metallic profile" for a wide range of clinical applications.
Impact:
- Expands possibilities in clinical chemistry, clinical toxicology, forensic toxicology, workplace testing, and environmental exposure studies.
- Enables large-scale epidemiologic studies through advanced analytical capabilities.
- Provides a more comprehensive understanding of metal exposure and its health implications.
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