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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Related Experiment Video

Updated: Jun 10, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
04:40

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Cancer-associated thrombosis.

John Winters1, David Garcia

  • 1Department of Internal Medicine, University of New Mexico School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.

Hematology/Oncology Clinics of North America
|July 28, 2010
PubMed
Summary
This summary is machine-generated.

Venous thromboembolic events are a serious complication in cancer patients, increasing morbidity and mortality. Understanding the complex links between cancer and thrombosis is crucial for effective prevention and treatment strategies.

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Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

Area of Science:

  • Oncology
  • Hematology
  • Translational Research

Background:

  • Venous thromboembolic events (VTE) are frequent in patients with malignancy.
  • Cancer is associated with a procoagulant state, increasing thrombosis risk.
  • VTE in cancer patients leads to significant morbidity and mortality.

Purpose of the Study:

  • To review the current understanding of the relationship between cancer and thrombosis.
  • To highlight the complexity of managing VTE in malignancy.
  • To emphasize the importance of evidence-based management and guidelines.

Main Methods:

  • Review of recent translational research.
  • Analysis of the multifaceted mechanisms linking cancer and thrombosis.
  • Consideration of clinical practice guidelines for VTE management in cancer.

Main Results:

  • Significant advancements in understanding cancer-thrombosis links.
  • Recognition of VTE as a life-threatening complication in active malignancy.
  • Complexity in prevention and treatment decisions for VTE in cancer patients.

Conclusions:

  • An evidence-based approach is essential for managing VTE in cancer.
  • Adherence to practice guidelines can improve patient outcomes.
  • Further research is needed to fully elucidate cancer-related thrombosis mechanisms.