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[NiII(3-OMe-salophene)]: a potent agent with antitumor activity
Soo-Young Lee1, Annegret Hille, Corazon Frias
1Department of Pediatric Oncology/Hematology, University Medical Center Charite, Berlin, Germany.
Abstract:
In this study, we investigated the anticancer properties of methoxy-substituted nickel(II)(salophene) derivatives. We demonstrated that the most active complex [NiII(3-OMe-salophene)] is not necrotic in Burkitt-like lymphoma cells (BJAB) and human B-cell precursor cells (Nalm-6). [NiII(3-OMe-salophene)] inhibited proliferation and induced apoptosis in a concentration dependent manner, giving evidence for the involvement of CD95 receptor-mediated, extrinsic pathway. Furthermore, [NiII(3-OMe-salophene)] overcame vincristine drug resistance in BJAB and Nalm-6 cells.
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