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Published on: September 5, 2017
Recurrence after treatment for pulmonary multidrug-resistant tuberculosis
Mercedes C Becerra1, Sasha C Appleton, Molly F Franke
1Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA. mbecerra@post.harvard.edu
Summary
Recurrent tuberculosis after treatment remains a concern. A Peruvian study found an upper-bound relapse rate of 5.2% among adults treated with individualized multidrug-resistant tuberculosis regimens.
Area of Science:
- Infectious Diseases
- Public Health
- Clinical Medicine
Background:
- Multidrug-resistant tuberculosis (MDR-TB) poses a significant global health challenge.
- Individualized treatment regimens are employed for MDR-TB, but recurrence rates require careful evaluation.
Purpose of the Study:
- To estimate the proportion of tuberculosis recurrence within two years among adults cured by individualized multidrug-resistant tuberculosis regimens in Peru.
- To establish an upper-bound estimate for true relapse to guide the development of improved treatment strategies.
Main Methods:
- A cohort of 310 adults treated with individualized MDR-TB regimens in Peru was followed for at least 24 months.
- The proportion of individuals experiencing recurrent tuberculosis was calculated.
- An upper-bound estimate for true relapse was determined by assuming all recurrence episodes were due to the original infection.
Main Results:
- Out of 310 individuals with at least 24 months of follow-up, 16 experienced recurrent tuberculosis.
- The upper-bound estimate for true relapse was 5.2% (95% confidence interval, 3.0%-8.2%).
Conclusions:
- The study provides a critical upper-bound estimate for relapse rates following individualized MDR-TB treatment.
- This estimate serves as a benchmark for future treatment regimens aiming for improved efficacy and reduced recurrence.
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