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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

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Updated: Jun 10, 2026

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes
06:35

Isolation of Murine Intestinal Mesenchyme Resulting in a High Yield of Telocytes

Published on: March 24, 2023

Intestinal mesenchymal cells.

I V Pinchuk1, R C Mifflin, J I Saada

  • 1Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555-0764, USA. ivpinchu@utmb.edu

Current Gastroenterology Reports
|August 7, 2010
PubMed
Summary
This summary is machine-generated.

The intestinal lamina propria contains mesenchymal cells like myofibroblasts and fibroblasts. These cells are crucial for intestinal development, stem cell function, and may play roles in inflammation and cancer.

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Published on: July 15, 2016

Area of Science:

  • Gastroenterology
  • Cell Biology
  • Developmental Biology

Background:

  • The intestinal lamina propria harbors diverse non-hematopoietic mesenchymal cells.
  • These cells include myofibroblasts, fibroblasts, pericytes, stromal stem cells, and smooth muscle.
  • Their roles in intestinal function and disease are increasingly recognized.

Purpose of the Study:

  • To review the functional anatomy and origins of intestinal mesenchymal cells.
  • To explore their involvement in intestinal mucosal morphogenesis and the stem cell niche.
  • To discuss emerging roles of myofibroblasts and mesenchymal cells in intestinal diseases.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of functional anatomy and embryonic origins.
  • Consideration of recent findings on myofibroblast and mesenchymal cell functions.

Main Results:

  • Mesenchymal cells are integral to the intestinal structure and stem cell niche.
  • Myofibroblasts exhibit nonprofessional immune functions.
  • Their roles in intestinal cancer and inflammation are under investigation.

Conclusions:

  • Mesenchymal cells are critical for intestinal development and homeostasis.
  • Further research is needed to fully elucidate their functions in health and disease.
  • Understanding these cells offers potential therapeutic targets for gastrointestinal disorders.