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Updated: Jun 10, 2026

Expression, Solubilization, and Purification of Eukaryotic Borate Transporters
Published on: March 7, 2019
Tripodal transmembrane transporters for bicarbonate
Nathalie Busschaert1, Philip A Gale, Cally J E Haynes
1School of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK.
New tripodal tris-thiourea receptors facilitate chloride and bicarbonate transport. These compounds represent a novel class of agents for bicarbonate transport applications.
Area of Science:
- Supramolecular Chemistry
- Anion Transport
Background:
- Anion transport is crucial in biological systems.
- Developing synthetic agents for anion transport is an active research area.
Purpose of the Study:
- To synthesize and characterize novel tripodal tris-thiourea receptors.
- To investigate the chloride and bicarbonate transport capabilities of these receptors.
Main Methods:
- Synthesis of tripodal tris-thiourea ligands.
- Anion binding studies.
- Transport assays to evaluate chloride and bicarbonate permeability.
Main Results:
- Successfully synthesized easy-to-make tripodal tris-thiourea receptors.
- Demonstrated the capability of these receptors for effective chloride and bicarbonate transport.
Conclusions:
- Tris-thiourea receptors represent a new class of synthetic bicarbonate transport agents.
- These findings open avenues for developing new tools in anion transport research.
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