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[Possible daptomycin-induced organizing pneumonia]

Turid Snekloth Søndergaard1, Helga Schumacher, Kirsten Norup

  • 1Klinisk Mikrobiologisk Afdeling, Regionshospitalet Herning, 7400 Herning, Denmark. turids@mail.tele.dk

Ugeskrift for Laeger
|August 11, 2010
PubMed

Insights

A rare case of drug-induced organizing pneumonia occurred in a patient treated with daptomycin for aortic valve endocarditis. Symptoms resolved after discontinuing daptomycin, suggesting a link between the antibiotic and the lung condition.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Pharmacology

Background:

  • A 75-year-old male presented with acute infective aortic valve endocarditis caused by Enterococcus faecalis.
  • The patient was treated with intravenous daptomycin and ceftriaxone.
  • A potential secondary infection with a ceftriaxone-resistant organism, such as Legionella, was considered.

Observation:

  • The patient developed organizing pneumonia during daptomycin therapy.
  • Symptoms of pneumonia emerged following the initiation of antibiotic treatment.
  • No Legionella antigen was detected in urine samples.

Findings:

  • Discontinuation of daptomycin led to the resolution of organizing pneumonia symptoms.
  • The clinical presentation suggests a possible drug-induced organizing pneumonia.
  • Ceftriaxone and subsequent ciprofloxacin/rifampicin treatments did not appear to be the primary cause.

Implications:

  • This case highlights a rare adverse reaction to daptomycin, specifically organizing pneumonia.
  • Clinicians should consider drug-induced lung injury in patients presenting with new respiratory symptoms during daptomycin treatment.
  • Further investigation into the mechanisms of daptomycin-induced pulmonary toxicity may be warranted.

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